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A Simple Weekly Routine For Applying Your Hormone Cream

Remembering when to apply your cream, and where, can sometimes be confusing but my simple guide helps make it easier to get the maximum benefit from it.


It happens to all of us, you read the instructions, then you lose them, or can’t remember exactly what they said when you need to apply your cream.

This is one of the most common questions I am asked, so together with Dr Tony Coope I devised an updated simple regime that I thought would be helpful to share with you.

Firstly, do remember that everyone is different and your response will be as unique to you as are your symptoms and their severity. Some women require more hormone cream to help alleviate severe symptoms, while others can use less, and factors such as stress will impact your hormones and mean your symptoms may need extra help.

However it does make sense that everyone starts off with the same dosage and then monitors their symptoms. So if you are new, make sure you begin with the recommended double dose of two pea sized amounts of cream twice daily for the first month of use to establish good hormone levels.

After the first month if your symptoms are coming under control you can go on to the maintenance dose of just one pea sized amount of cream twice daily on your regime and once they are fully controlled then try cutting back on the amount each month and monitor your symptoms.

If your symptoms are severe, or return, then either stay on the initial double dose or go back to a slightly higher dose than the maintenance amount. Monitor your progress and go to the maintenance dose when you feel symptoms are under control.

A simple application routine

All hormone creams should be gently stroked onto the skin, they do not need to be rubbed in vigorously.

You need to apply to a different area each day and a twice daily application gives a more even distribution over each 24 hours.

To optimise absorption, it makes sense to rotate applications through different sites, avoiding the possibility of saturation if only one or a few are used.

A convenient, easy to apply and to remember, routine is:

Day 1. (am.) L inner thigh     (pm.) R inner thigh

Day 2.    L half of abdomen    R half of abdomen

Day 3.    L inner forearm         R inner forearm

Day 4.    L inner upper arm     R inner upper arm

Day 5.    as for Day 1 and continue this rotation until the month’s cycle is completed.

The principle here is that all the the sites have smooth soft skin which optimises absorption through the epidermis into the capillary layer.

How many days do I apply?

For women in their reproductive phase of life with a regular 28 day cycle, you apply on a 2 week on and 2 week off cycle.

Day 1 is the first day of your period so you apply the cream from days 14-28 of your cycle so you are following as close as is realistic to the body’s natural hormone production.

If your cycle is not 28 days then adjust this so you always have two weeks of application – eg if a 24 day cycle you would apply from days 10-24.

Premenopause/Menopause/Post Menopause with irregular cycles, or no cycle at all, then a 3 week on/1 week off  routine is best.

When there is no cycle you can commence the cream at any point and use for the 3 weeks, but if you get a bleed at any point in the 3 weeks (as can occur at perimenopause) then you stop the cream. You then wait for 1 week and start a completely new 24 day cycle.

If you are finding your symptoms returning during the break then it can be shortened – and initially you can go for up to 3 months, but no longer, without a break to get severe symptoms under control.

Do I really need a break?

Whatever your age or circumstances, whether you have had a hysterectomy or very irregular periods, or no periods at all, it is very important to take the break to allow the cell receptors time to rest and prevent the chance of you overusing any single one.

If you do not take the break you run the risk of actually absorbing less hormone to deal with your symptoms as once that site is ‘full’ it can’t take the hormone and use it as it can when applied in rotation.

More information:

If you need more assistance please email for individual help with your symptoms or application usage.

Wellsprings have also developed a range of supplements that can be used in combination with either our Serenity or 20-1 creams.

You can find details of all of our products here, along with more information on hormone health that you might find useful: